Journal: Scientific Reports

Article Title: Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition

doi: 10.1038/srep00019

Figure Lengend Snippet: (a) Z projection of a confocal stack shows a PECAM1-immunolabeled microvessel (green) with cerebral amyloid angiopathy (CAA) in a CRND8 transgenic mouse. Single optical sections demonstrate the differential labeling of amyloid (yellow arrowheads) with MX (T 1 ) and TR (T 2 ) over a 60 day interval. (b,c) A mutant tau transgenic mouse (P301S) labeled with fluoro-styrylbenzene (FSB) (T 1 ) and TR (T 2 ) demonstrates the feasibility of detecting pre-existing (b) and new intracellular neurofibrillary tangles (NFT) (c). (d) Images of human tissue from an Alzheimer's patient labeled with both FSB and TR (T 1 ) demonstrate strong overlap between the plaque labels. (e) The area of synaptophysin immunoreactive dystrophy was traced (pseudo-color grey) and plaque labels at T 1 were thresholded (cyan and red lines) to simulate different time points. Scale bar, 10 µm. (f) Labeling of NFTs with FSB and TR in human AD tissue demonstrates colocalization at T 1 .

Article Snippet: For NFT imaging, MAPT*P301S) mice were used (Jackson Laboratories).

Techniques: Immunolabeling, Transgenic Assay, Labeling, Mutagenesis

Journal: Trials

Article Title: Neurofeedback training for alcohol dependence versus treatment as usual: study protocol for a randomized controlled trial

doi: 10.1186/s13063-016-1607-7

Figure Lengend Snippet: Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) diagram

Article Snippet: The main aims of the Cardiff arm of BRAINTRAIN are (1) to determine whether participants who receive rtfMRI NFT can down-regulate their brain activation while they are exposed to alcohol stimuli (or up-regulate their brain activation in response to pictures related to healthy goal pursuits), and (2) to determine whether, compared to control participants, the training helps patients to reduce their urges to drink and their consumption of alcohol and to bring about other improvements in their functioning.

Techniques: Control